BindingDB BDBM16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid

BDBM16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239

SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1

InChI Key InChIKey=MLDQJTXFUGDVEO-UHFFFAOYSA-N

Data 26 KI 352 IC50 1273 Kd 3 EC50

PDB links: 8 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16673

Serine/threonine-protein kinase 17B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: >1.00E+4nMAssay Description:Binding affinity to DRAK2More data for this Ligand-Target Pair

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Serine/threonine-protein kinase 17B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: >1.00E+4nMAssay Description:Binding constant for DRAK2 kinase domainMore data for this Ligand-Target Pair

PDB
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antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
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Details Article PubMed

Serine/threonine-protein kinase 17B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Kd: >1.00E+4nMAssay Description:Binding constant for full-length DRAK2More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
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Details Article PubMed

Filter my 1654 hits

Targets 423▿
- Vascular endothelial growth factor receptor 2 102
- Serine/threonine-protein kinase B-raf 58
- Receptor-type tyrosine-protein kinase FLT3 45
- Tyrosine-protein kinase ABL1 37
- Epidermal growth factor receptor 35
- RAF proto-oncogene serine/threonine-protein kinase 32
- Mast/stem cell growth factor receptor Kit 30
- Proto-oncogene tyrosine-protein kinase receptor Ret 21
- Platelet-derived growth factor receptor beta 18
- Mitogen-activated protein kinase 14 17
- Vascular endothelial growth factor receptor 3 14
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 13
- Cyclin-dependent kinase 8 13
- Fibroblast growth factor receptor 1 11
- Angiopoietin-1 receptor 10
- Ephrin type-B receptor 4 10
- Ephrin type-A receptor 6 10
- Vascular endothelial growth factor receptor 1 10
- Serine/threonine-protein kinase TNNI3K 7
- Discoidin domain-containing receptor 2 7
- Ribosomal protein S6 kinase alpha-6 7
- Aurora kinase A 7
- Serine/threonine-protein kinase PLK4 6
- Mitogen-activated protein kinase 11 6
- Macrophage colony-stimulating factor 1 receptor 6
- MAP kinase-interacting serine/threonine-protein kinase 2 6
- Receptor-interacting serine/threonine-protein kinase 2 6
- Platelet-derived growth factor receptor alpha 6
- Ribosomal protein S6 kinase alpha-4 6
- Tyrosine-protein kinase FRK 6
- Receptor tyrosine-protein kinase erbB-2 6
- Ribosomal protein S6 kinase alpha-5 6
- Ribosomal protein S6 kinase alpha-2 6
- Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] 6
- Ribosomal protein S6 kinase alpha-1 6
- Hepatocyte growth factor receptor 6
- Ephrin type-A receptor 8 6
- Glycogen synthase kinase-3 beta 6
- Fibroblast growth factor receptor 3 6
- Serine/threonine-protein kinase PLK1 5
- Tyrosine-protein kinase Lck 5
- Ephrin type-A receptor 2 5
- Ephrin type-A receptor 5 5
- Ephrin type-A receptor 4 5
- Mitogen-activated protein kinase 12 5
- Tyrosine-protein kinase ABL2 5
- Cyclin-C 5
- High affinity nerve growth factor receptor 5
- Tyrosine-protein kinase Mer 5
- Tyrosine-protein kinase JAK1 5
- Serine/threonine-protein kinase B-raf [V600E] 5
- Receptor-interacting serine/threonine-protein kinase 1 5
- Serine/threonine-protein kinase 36 5
- Ephrin type-B receptor 1 5
- Cyclin-dependent kinase 19 5
- Serine/threonine-protein kinase 10 5
- STE20-like serine/threonine-protein kinase 5
- Mitogen-activated protein kinase kinase kinase kinase 5 5
- Epithelial discoidin domain-containing receptor 1 5
- Non-receptor tyrosine-protein kinase TYK2 5
- Myosin light chain kinase, smooth muscle 5
- Aurora kinase B 5
- Ephrin type-A receptor 1 4
- Mitogen-activated protein kinase 1 4
- Ephrin type-A receptor 3 4
- Mitogen-activated protein kinase 3 4
- Dual specificity protein kinase TTK 4
- Tyrosine-protein kinase receptor Tie-1 4
- Death-associated protein kinase 3 4
- Mitogen-activated protein kinase 9 4
- NT-3 growth factor receptor 4
- Tyrosine-protein kinase receptor UFO 4
- Cyclin-dependent kinase 7 4
- Cyclin-dependent kinase 5 4
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 4
- Non-receptor tyrosine-protein kinase TNK1 4
- Myosin light chain kinase 2, skeletal/cardiac muscle 4
- Cyclin-dependent kinase 17 4
- LIM domain kinase 1 4
- Serine/threonine-protein kinase NLK 4
- Mitogen-activated protein kinase kinase kinase kinase 4 4
- Mitogen-activated protein kinase 15 4
- Mitogen-activated protein kinase kinase kinase 20 4
- Fibroblast growth factor receptor 2 4
- Cyclin-dependent kinase 14 4
- Tyrosine-protein kinase Srms 4
- Aurora kinase C 4
- Serine/threonine-protein kinase PLK3 4
- Mitogen-activated protein kinase kinase kinase 7 4
- Citron Rho-interacting kinase 4
- Tyrosine-protein kinase Lyn 4
- Focal adhesion kinase 1 4
- MAP kinase-interacting serine/threonine-protein kinase 1 4
- RAC-alpha serine/threonine-protein kinase 4
- Cyclin-dependent kinase 2 4
- Serine/threonine-protein kinase 33 4
- Ephrin type-B receptor 2 4
- BDNF/NT-3 growth factors receptor 4
- Muscle, skeletal receptor tyrosine-protein kinase 4
- Cyclin-G-associated kinase 3
- Tyrosine-protein kinase Tec 3
- BMP-2-inducible protein kinase 3
- Cyclin-dependent kinase 11B 3
- Cyclin-dependent kinase 11A 3
- LIM domain kinase 2 3
- ALK tyrosine kinase receptor 3
- NUAK family SNF1-like kinase 2 3
- Serine/threonine-protein kinase Nek9 3
- Serine/threonine-protein kinase Nek7 3
- Glycogen synthase kinase-3 alpha 3
- Serine/threonine-protein kinase Nek6 3
- Calcium/calmodulin-dependent protein kinase type 1 3
- NUAK family SNF1-like kinase 1 3
- Serine/threonine-protein kinase Nek5 3
- Calcium/calmodulin-dependent protein kinase type II subunit beta 3
- AP2-associated protein kinase 1 3
- Serine/threonine-protein kinase Nek2 3
- Serine/threonine-protein kinase Nek1 3
- Serine/threonine-protein kinase receptor R3 3
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 3
- MAP/microtubule affinity-regulating kinase 3 3
- Homeodomain-interacting protein kinase 4 3
- Serine/threonine-protein kinase PAK 1 3
- Homeodomain-interacting protein kinase 3 3
- Protein kinase C theta type 3
- Serine/threonine-protein kinase PAK 2 3
- Serine/threonine-protein kinase PAK 3 3
- Dual specificity mitogen-activated protein kinase kinase 2 3
- Serine/threonine-protein kinase PAK 4 3
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 3
- Serine/threonine-protein kinase tousled-like 2 3
- Dual specificity mitogen-activated protein kinase kinase 3 3
- Serine/threonine-protein kinase PAK 5 3
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 3
- Serine/threonine-protein kinase PAK 6 3
- Serine/threonine-protein kinase tousled-like 1 3
- Tyrosine-protein kinase JAK3 3
- Tyrosine-protein kinase JAK2 3
- Dual specificity mitogen-activated protein kinase kinase 1 3
- MAP/microtubule affinity-regulating kinase 4 3
- Dual specificity mitogen-activated protein kinase kinase 6 3
- Dual specificity mitogen-activated protein kinase kinase 4 3
- Tyrosine-protein kinase ZAP-70 3
- Casein kinase I isoform gamma-3 3
- Casein kinase I isoform gamma-2 3
- Casein kinase I isoform epsilon 3
- Casein kinase I isoform gamma-1 3
- Serine/threonine-protein kinase 38-like 3
- Myosin-IIIb 3
- Myosin-IIIa 3
- Tyrosine-protein kinase BTK 3
- Tyrosine-protein kinase ITK/TSK 3
- Myotonin-protein kinase 3
- Protein kinase C eta type 3
- Insulin-like growth factor 1 receptor 3
- Activin receptor type-1 3
- Bone morphogenetic protein receptor type-1A 3
- Tyrosine-protein kinase Blk 3
- Serine/threonine-protein kinase 16 3
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 3
- Homeodomain-interacting protein kinase 2 3
- Homeodomain-interacting protein kinase 1 3
- Wee1-like protein kinase 3
- Casein kinase I isoform delta 3
- Cyclin-dependent kinase 18 [3-474] 3
- Ankyrin repeat and protein kinase domain-containing protein 1 3
- Serine/threonine-protein kinase 26 3
- Serine/threonine-protein kinase 24 3
- Dual specificity testis-specific protein kinase 1 3
- Serine/threonine-protein kinase 25 3
- Ephrin type-B receptor 3 3
- Tyrosine-protein kinase TXK 3
- MAP kinase-activated protein kinase 2 3
- MAP kinase-activated protein kinase 5 3
- Bile salt export pump 3
- Death-associated protein kinase 2 3
- Death-associated protein kinase 1 3
- Serine/threonine-protein kinase D2 3
- Tyrosine-protein kinase Fer 3
- Serine/threonine-protein kinase D3 3
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 3
- TGF-beta receptor type-2 3
- Serine/threonine-protein kinase D1 3
- Calcium/calmodulin-dependent protein kinase type II subunit delta 3
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 3
- Proto-oncogene tyrosine-protein kinase ROS 3
- Cyclin-dependent kinase 9 3
- Serine/threonine-protein kinase pim-3 3
- Serine/threonine-protein kinase TAO1 3
- Serine/threonine-protein kinase pim-1 3
- Calcium/calmodulin-dependent protein kinase kinase 1 3
- Serine/threonine-protein kinase pim-2 3
- Serine/threonine-protein kinase DCLK1 3
- Cyclin-dependent kinase 4 3
- Calcium/calmodulin-dependent protein kinase kinase 2 3
- Serine/threonine-protein kinase DCLK2 3
- Cyclin-dependent kinase 3 3
- Serine/threonine-protein kinase DCLK3 3
- Testis-specific serine/threonine-protein kinase 1 3
- Cyclin-dependent kinase 16 3
- Interferon-induced, double-stranded RNA-activated protein kinase 3
- Protein kinase C epsilon type 3
- Mitogen-activated protein kinase kinase kinase kinase 3 3
- Bone morphogenetic protein receptor type-2 3
- Mitogen-activated protein kinase kinase kinase kinase 1 3
- Serine/threonine-protein kinase MRCK alpha 3
- Protein-tyrosine kinase 6 3
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 3
- Casein kinase II subunit alpha 3
- Activin receptor type-1B 3
- Leukocyte tyrosine kinase receptor 3
- Cytoplasmic tyrosine-protein kinase BMX 3
- Myosin light chain kinase family member 4 3
- Mitogen-activated protein kinase kinase kinase 9 3
- RAC-gamma serine/threonine-protein kinase 3
- Mitogen-activated protein kinase kinase kinase 5 3
- Interleukin-1 receptor-associated kinase 3 3
- Serine/threonine-protein kinase A-Raf 3
- Atypical kinase COQ8B, mitochondrial 3
- Mitogen-activated protein kinase kinase kinase 4 3
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 3
- Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] 3
- cGMP-dependent protein kinase 2 3
- cGMP-dependent protein kinase 1 3
- Proto-oncogene tyrosine-protein kinase Src 3
- Serine/threonine-protein kinase SIK2 3
- Tyrosine-protein kinase Fes/Fps 3
- Activin receptor type-2B 3
- Serine/threonine-protein kinase SIK1 3
- Activin receptor type-2A 3
- 3-phosphoinositide-dependent protein kinase 1 3
- Serine/threonine-protein kinase 17A 3
- Serine/threonine-protein kinase 3 3
- Mitogen-activated protein kinase 4 3
- Serine/threonine-protein kinase 17B 3
- Serine/threonine-protein kinase 4 3
- Dual specificity protein kinase CLK1 3
- Protein kinase C delta type 3
- SRSF protein kinase 2 3
- Dual specificity protein kinase CLK4 3
- Dual specificity protein kinase CLK3 3
- Dual specificity protein kinase CLK2 3
- Protein-tyrosine kinase 2-beta 3
- Serine/threonine-protein kinase N2 3
- Mitogen-activated protein kinase 6 3
- cAMP-dependent protein kinase catalytic subunit beta 3
- Mitogen-activated protein kinase 7 3
- Mitogen-activated protein kinase 8 3
- Calcium/calmodulin-dependent protein kinase type IV 3
- Serine/threonine-protein kinase N1 3
- Tyrosine-protein kinase SYK 3
- Ribosomal protein S6 kinase alpha-3 3
- Calcium/calmodulin-dependent protein kinase type 1D 3
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3
- Serine/threonine-protein kinase RIO1 3
- Serine/threonine-protein kinase LATS1 3
- Serine/threonine-protein kinase RIO3 3
- Serine/threonine-protein kinase 32B 3
- Fibroblast growth factor receptor 4 3
- Serine/threonine-protein kinase 32C 3
- Tyrosine-protein kinase Fgr 3
- Insulin receptor 3
- Tyrosine-protein kinase HCK 3
- Atypical kinase COQ8A, mitochondrial 3
- Serine/threonine-protein kinase PLK2 3
- Insulin receptor-related protein 3
- Tyrosine-protein kinase receptor TYRO3 3
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 3
- RAC-beta serine/threonine-protein kinase 3
- Mitogen-activated protein kinase 10 3
- Serine/threonine-protein kinase BRSK1 3
- Serine/threonine-protein kinase LATS2 3
- Tyrosine-protein kinase Fyn 3
- Tyrosine-protein kinase CSK 3
- Serine/threonine-protein kinase BRSK2 3
- Maternal embryonic leucine zipper kinase 3
- Serine/threonine-protein kinase MARK1 3
- Serine/threonine-protein kinase MARK2 3
- TRAF2 and NCK-interacting protein kinase 3
- Serine/threonine-protein kinase Chk1 3
- cAMP-dependent protein kinase catalytic subunit PRKX 3
- SRSF protein kinase 1 3
- Tyrosine-protein kinase Yes 3
- Serine/threonine-protein kinase MRCK beta 3
- Serine/threonine-protein kinase MRCK gamma 3
- Mitogen-activated protein kinase kinase kinase 10 3
- Mitogen-activated protein kinase kinase kinase 11 3
- Casein kinase II subunit alpha' 3
- Serine/threonine-protein kinase STK11 3
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2
- Receptor tyrosine-protein kinase erbB-4 2
- Rhodopsin kinase GRK1 2
- Serine/threonine-protein kinase 38 2
- Serine/threonine-protein kinase TAO3 2
- Serine/threonine-protein kinase 35 2
- Uncharacterized serine/threonine-protein kinase SBK3 2
- Receptor tyrosine-protein kinase erbB-3 2
- Mitogen-activated protein kinase kinase kinase kinase 2 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Casein kinase I isoform alpha-like 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Cyclin-dependent kinase 15 2
- Mitogen-activated protein kinase kinase kinase 6 2
- Macrophage-stimulating protein receptor 2
- Interleukin-1 receptor-associated kinase 1 2
- Mitogen-activated protein kinase kinase kinase 2 2
- Cyclin-dependent kinase-like 3 2
- Mitogen-activated protein kinase kinase kinase 1 2
- Cyclin-dependent kinase-like 2 2
- Serine/threonine-protein kinase SIK3 [59-1321] 2
- Mitogen-activated protein kinase kinase kinase 3 2
- Serine/threonine-protein kinase ICK 2
- Cyclin-dependent kinase-like 5 2
- Microtubule-associated serine/threonine-protein kinase 1 2
- Megakaryocyte-associated tyrosine-protein kinase 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Rho-associated protein kinase 2 2
- Rho-associated protein kinase 1 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- Serine/threonine-protein kinase ULK1 2
- 5-hydroxytryptamine receptor 2A 2
- Serine/threonine-protein kinase ULK2 2
- Serine/threonine-protein kinase ULK3 2
- Mitogen-activated protein kinase kinase kinase 19 2
- Ephrin type-A receptor 7 2
- Mitogen-activated protein kinase kinase kinase 15 2
- SRSF protein kinase 3 2
- G protein-coupled receptor kinase 4 2
- Bone morphogenetic protein receptor type-1B 2
- Receptor-interacting serine/threonine-protein kinase 4 2
- Serine/threonine-protein kinase TBK1 2
- Ribosomal protein S6 kinase beta-1 2
- Hormonally up-regulated neu tumor-associated kinase 2
- Calcium/calmodulin-dependent protein kinase type 1G 2
- Serine/threonine-protein kinase RIO2 2
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 2
- Serine/threonine-protein kinase OSR1 2
- Inhibitor of nuclear factor kappa-B kinase subunit beta 2
- Serine/threonine-protein kinase NIM1 2
- Serine/threonine-protein kinase MAK 2
- Serine/threonine-protein kinase/endoribonuclease IRE1 2
- Mitogen-activated protein kinase 13 2
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 2
- Wee1-like protein kinase 2 2
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma 2
- Casein kinase I isoform alpha 2
- Misshapen-like kinase 1 2
- cAMP-dependent protein kinase catalytic subunit alpha 2
- eIF-2-alpha kinase GCN2 2
- RuvB-like 2 2
- Serine/threonine-protein kinase Chk2 2
- Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] 2
- Activated CDC42 kinase 1 2
- Bifunctional epoxide hydrolase 2 2
- Ephrin type-B receptor 6 2
- Rhodopsin kinase GRK7 2
- Mitogen-activated protein kinase kinase kinase 13 2
- STE20/SPS1-related proline-alanine-rich protein kinase 2
- Phosphatidylinositol 4-kinase beta 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 2
- Calcium-dependent protein kinase 1 1
- Neurotensin receptor type 1 1
- Peripheral plasma membrane protein CASK 1
- Dual serine/threonine and tyrosine protein kinase 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1
- Tubulin alpha-1A chain 1
- Cyclin-dependent kinase 6 1
- Serine/threonine-protein kinase PknB 1
- Serine/threonine-protein kinase PRP4 homolog 1
- Serine/threonine-protein kinase TAO2 1
- Cyclin-dependent kinase-like 1 [2-358] 1
- Discoidin domain-containing receptor 2 [A642S] 1
- Cyclin-dependent kinase 2 homolog 1
- Serine/threonine-protein kinase B-raf [409-765] 1
- Broad substrate specificity ATP-binding cassette transporter ABCG2 1
- Cyclin-dependent kinase 13 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 1
- Protein kinase C iota type 1
- Interleukin-1 receptor-associated kinase 4 1
- Transient receptor potential cation channel subfamily M member 6 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek3 1
- Serine/threonine-protein kinase B-raf [410-766,V600E] 1
- Serine/threonine-protein kinase VRK2 1
- Putative glycogen synthase kinase 3 alpha 1
- Tyrosine-protein kinase ABL1 [T315I] 1
- Protein delta homolog 1 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- 5-hydroxytryptamine receptor 2C 1
- 5-hydroxytryptamine receptor 2B 1
- Carbonic anhydrase 7 1
- Serine/threonine-protein kinase Sgk3 1
- Carbonic anhydrase 9 1
- 5-hydroxytryptamine receptor 7 1
- Carbonic anhydrase 2 1
- 5-hydroxytryptamine receptor 6 1
- RAF proto-oncogene serine/threonine-protein kinase [305-648] 1
- Myosin light chain kinase 3 1
- Serine/threonine-protein kinase Nek11 1
- Carbonic anhydrase 1 1
- Serine/threonine-protein kinase mTOR 1
- Eukaryotic translation initiation factor 2-alpha kinase 1 1
- Poly [ADP-ribose] polymerase tankyrase-2 1
- Receptor-type tyrosine-protein kinase FLT3 [D835H] 1
- SNF-related serine/threonine-protein kinase 1
- Receptor-interacting serine/threonine-protein kinase 3 1
- Aromatase 1
- Serine/threonine-protein kinase 32A 1
- 5-hydroxytryptamine receptor 1A 1
- Receptor-type tyrosine-protein kinase FLT3 [D835Y] 1
- Cytochrome P450 3A4 1
- U4/U6 small nuclear ribonucleoprotein Prp4 1
- 5-hydroxytryptamine receptor 5A 1
- Protein kinase C alpha type 1
- RuvB-like 1 1
- Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1
- Receptor-type tyrosine-protein kinase FLT3 [N841I] 1
- Serine/threonine-protein kinase SBK1 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Ephrin type-A receptor 3 [1-975] 1
- Tyrosine-protein kinase ABL1 [1-999,Q252H] 1
- ...
Publications 50▿
- Nat Biotechnol 29: 1046-51 (2011) 442
- Blood 114: 2984-92 (2009) 360
- Nat Biotechnol 26: 127-32 (2008) 317
- Nat Biotechnol 23: 329-36 (2005) 41
- PubChem Bioassay (2008) 28
- Proc Natl Acad Sci U S A 104: 19936-41 (2007) 17
- J Med Chem 55: 5749-59 (2012) 13
- J Med Chem 64: 11747-11773 (2021) 11
- Cancer Res 64: 7099-109 (2004) 10
- J Med Chem 61: 5073-5092 (2018) 10
- Bioorg Med Chem 19: 5342-51 (2011) 7
- J Med Chem 64: 15651-15670 (2021) 6
- Nat Chem Biol 2: 358-64 (2006) 6
- Eur J Med Chem 179: 707-722 (2019) 6
- J Med Chem 53: 1413-37 (2010) 5
- J Med Chem 62: 2428-2446 (2019) 5
- Eur J Med Chem 53: 254-63 (2012) 5
- Eur J Med Chem 168: 315-329 (2019) 5
- J Med Chem 64: 12022-12048 (2021) 5
- Eur J Med Chem 163: 243-255 (2019) 4
- Bioorg Med Chem 56: (2022) 4
- Eur J Med Chem 199: (2020) 4
- Bioorg Med Chem Lett 22: 4654-9 (2012) 4
- Eur J Med Chem 163: 37-53 (2019) 4
- Eur J Med Chem 215: (2021) 4
- Eur J Med Chem 182: (2019) 4
- Eur J Med Chem 210: (2021) 4
- US Patent US11505527 (2022) 4
- Biochemistry 46: 9551-63 (2007) 4
- Bioorg Med Chem 19: 4173-82 (2011) 4
- Biochem J 408: 297-315 (2007) 4
- Bioorg Med Chem 18: 5738-48 (2010) 3
- US Patent US10774070 (2020) 3
- Eur J Med Chem 143: 1148-1164 (2018) 3
- Eur J Med Chem 163: 1-9 (2019) 3
- Eur J Med Chem 130: 86-106 (2017) 3
- Eur J Med Chem 94: 397-404 (2015) 3
- Eur J Med Chem 127: 275-285 (2017) 3
- Bioorg Med Chem Lett 29: 1605-1608 (2019) 3
- Eur J Med Chem 164: 440-447 (2019) 3
- Bioorg Med Chem 25: 5754-5763 (2017) 3
- Bioorg Med Chem 62: (2022) 3
- Eur J Med Chem 141: 373-385 (2017) 3
- Eur J Med Chem 100: 151-61 (2015) 3
- US Patent US9029401 (2015) 3
- US Patent US10227329 (2019) 3
- Eur J Med Chem 141: 506-518 (2017) 3
- Bioorg Med Chem 24: 750-8 (2016) 3
- Bioorg Med Chem 26: 2381-2391 (2018) 3
- J Med Chem 56: 1641-55 (2013) 3
- ...
Institutions 37▿
- Ambit Biosciences 1188
- Harvard Medical School 17
- National Institute Of Biological Sciences 13
- Xi'An Jiaotong University 12
- National Health Research Institutes 11
- University Of Arkansas For Medical Sciences 11
- Bayer Pharmaceuticals 10
- China Pharmaceutical University 10
- University Of South Australia 10
- Takeda Pharmaceutical 7
- Novartis Research Foundation 6
- Glaxosmithkline 6
- Blueprint Medicines 6
- The First Affiliated Hospital Of Xi'An Jiaotong University 6
- National Research Centre 6
- Schering-Plough 5
- Technische Universit£T Braunschweig 5
- West China Hospital Of Sichuan University 5
- Mansoura University 5
- Technische Universit£T Darmstadt 5
- Central South University 4
- Abbott Laboratories 4
- Ain Shams University 4
- Masaryk University 4
- University Of Florence 4
- University Of Dundee 4
- Kafrelsheikh University 4
- University Of Sharjah 4
- King Abdulaziz University 4
- Sichuan University/Collaborative Innovation Center Of Biotherapy 3
- The University Of Arizona 3
- The Regents of The University of California 3
- Jiangxi Science & Technology Normal University 3
- Yantai University 3
- Sichuan University 3
- California Institute Of Technology 3
- Cairo University 3
- ...
Affinity: 0.021 to 7.5E+6 nM▿
- Ki 26
- IC50 352
- Kd 1273
- EC50 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 1
Catalog Cmpds: 1